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  • 标题:Polymorphisms in PRKCDBP, a Transcriptional Target of TNF-α, Are Associated With Inflammatory Bowel Disease in Korean
  • 本地全文:下载
  • 作者:Kim, Jung-Wook ; Lee, Chang Kyun ; Kim, Hyo Jong
  • 期刊名称:Intestinal Research
  • 印刷版ISSN:1598-9100
  • 电子版ISSN:2288-1956
  • 出版年度:2015
  • 卷号:13
  • 期号:3
  • 页码:242-249
  • DOI:10.5217/ir.2015.13.3.242
  • 语种:English
  • 出版社:Korean Association for the Study of Intestinal Diseases
  • 摘要:Background/Aims

    Emerging data indicate that polymorphic sequence variations in the tumor necrosis factor alpha (TNF-α) gene may affect its production, and be associated with the risk of inflammatory bowel disease (IBD). PRKCDBP is a putative tumor suppressor gene and a transcriptional target of TNF-α. The aim of this case-control study is to explore the possible association of single nucleotide polymorphisms (SNPs) in PRKCDBP with the development of IBD in Koreans.

    Methods

    Genotyping analysis of four SNPs of PRKCDBP [rs35301211 (G210A), rs11544766 (G237C), rs12294600 (C797T), and rs1051992 (T507C)] was performed on 170 ulcerative colitis (UC),131 Crohn's disease (CD) patients, and 100 unrelated healthy controls using polymerase chain reaction and restriction fragment length polymorphism.

    Results

    Heterozygous configuration of three SNPs (G210A, G237C, and C797T) was very rare in both patients and healthy controls. However, allele frequencies of the T507C SNP showed a significant difference between UC patients and controls ( P =0.037). The CC genotype of the T507C SNP was identified in 46.6% (61 of 131) of CD and 49.4% (84 of 170) of UC patients, but only in 33.0% (33 of 100) of healthy controls. Furthermore, CC homozygosity was more prevalent than TC heterozygosity in both CD and UC patients versus controls ( P =0.016; gender-adjusted odds ratio [aOR], 2.16; 95% confidence interval [CI], 1.16-4.04 and P =0.009; aOR, 2.09; 95% CI, 1.193.64; respectively)

    Conclusions

    Our results suggest that the T507C SNP in PRKCDBP , a TNF-α-inducible gene, might be associated with susceptibility to IBD (particularly UC) development in Koreans.

  • 关键词:PRKCDBP; Polymorphisms, Single Nucleotide; Crohn disease; Colitis, Ulcerative
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