期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2021
卷号：118
期号：47
DOI：10.1073/pnas.2113095118
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Significance
Left-handedness occurs in roughly 10% of people, but whether it involves altered brain anatomy has remained unclear. We measured left to right asymmetry of the cerebral cortex in 28,802 right-handers and 3,062 left-handers. There were small average differences between the two handedness groups in brain regions important for hand control, language, vision, and working memory. Genetic influences on handedness were associated with some of these brain asymmetries, especially of language-related regions. This suggests links between handedness and language during human development and evolution. One implicated gene is
NME7, which also affects placement of the visceral organs (heart, liver, etc.) on the left to right body axis—a possible connection between brain and body asymmetries in embryonic development.
Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associated with two of these regional asymmetries, and 18 loci previously linked with left-handedness by genome-wide screening showed associations with one or more of these asymmetries. Implicated genes included six encoding microtubule-related proteins:
TUBB,
TUBA1B,
TUBB3,
TUBB4A,
MAP2, and
NME7—mutations in the latter can cause left to right reversal of the visceral organs. There were also two cortical regions where average thickness asymmetry was altered in left-handedness: on the postcentral gyrus and the inferior occipital cortex, functionally annotated with hand sensorimotor and visual roles. These cortical thickness asymmetries were not heritable. Heritable surface area asymmetries of language-related regions may link the etiologies of hand preference and language, whereas nonheritable asymmetries of sensorimotor cortex may manifest as consequences of hand preference.
