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  • 标题:PRESERVATION OF VITAMIN-E AGAINST NEPHROTOXIC EFFECT INDUCED BY SUBACUTE DICHLORVOS APPLICATION
  • 本地全文:下载
  • 作者:Gokhan Nur ; H Ahmet Deveci ; Evren Koc
  • 期刊名称:Fresenius Environmental Bulletin
  • 印刷版ISSN:1018-4619
  • 出版年度:2021
  • 卷号:30
  • 期号:7
  • 页码:8651-8659
  • 语种:English
  • 出版社:PSP Publishing
  • 摘要:In this study,it was aimed to determine the po-tential toxic effect of organophosphate dichlorvos applications, which is used as a broad spectrum in-secticide in agricultural activities through food chain and the protection of vitamin E against it. In this study,40 Spraque Dawley male rats were used. The corn oil was given intragastrically as 5 ml kg-1. In the second group,5 mg kg-1 dose of dichlorvos was applied intragastrically after dissolving in corn oil. The third group,120 mg kg-1 vitamin E application was started intragastrically by starting three days be-fore the application of dichlorvos, and the following days were applied in the same way at 5 mg kg-1 doses after 1 hour vit-E application.In the last group, vit-E was given intragastrically at a dose of only 120 mg kg-1. Histological examination ofrenal tissue re-vealed normal structures in control and Vitamin-E groups,whereas glomerular atrophy, inflammatory cell infiltrations and tubular degeneration areas were observed in the dichlorvos group. Vit-E in combina-tion with dichlorvos decreased the severity of the le-sions. PON and HDL levels were decreased com-pared to the control group and increased in MDA and NO levels due to toxicity caused by inflammation in the dichlorvos group. When Dichlorvos and vit-E were applied together, PON and HDL levels were in-creased and MDA and NO levels were decreased when compared to only dichlorvos group. It has been concluded that vit-E supplementation would be ben-eficialin addition to routine medical treatment in liv-ing beings exposed to dichlorvos poisoning.
  • 关键词:Dichlorvos;Vitamin-E;Nephrotoxicity;Oxidative stress;Subacute administration
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