摘要：Cataract, known as opacification of the lens in the eye, is one of the causes of blindness worldwide. The aim of this study was to investigate the potential protective effects of Hesperidin (HES) in an experi- mental cataract model with sodium selenite (Na2Se03) in male Wistar rats. Thirty-two Wistar- albino rat pups were assigned into four groups. All the rats, except for those in the Control group, were injected subcutaneously (s.c) Na2Se03 to induce ex- perimental cataract on the postnatal 10th day. Group1: Only saline (0.9 % NaCl) was administered by s.c, Group 2: Nuclear cataract was produced single dose20 umol/kg s.c. Na2Se03 on the postnatal 10th day, Group 3: HES was dissolved in saline solution and 100 mg/kg was administered by oral gavage for 4weeks. Group 4: Na2Se03 (20 umol/kg) + HES (100 mg/kg). The reduced glutathione (GSH), malondial- dehyde (MDA) and total antioxidant status (TAS) inlens supernatants were measured spectrophotometri- cally. Data were analyzed using the SPSS software package. One-way ANOVAs followed by post-hoc Bonferroni tests were used for statistical analysis (p. <0.05). It was observed that GSH and TAS levels decreased in the Na2Se03 group compared to the Control group, whereas MDA levels increased sig- nificantly. However in the Na2Se03+HES group, compared to the Na2Se03 group, GSH and TAS lev- els increased significantly while MDA levels were decreased. In our study, it was observed that Hesper- idin had positive effects on oxidative damage in the cataract model.
