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  • 标题:Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats
  • 本地全文:下载
  • 作者:Yiran Lang ; Rongyu Tang ; Yafei Liu
  • 期刊名称:Biosensors
  • 电子版ISSN:2079-6374
  • 出版年度:2021
  • 卷号:11
  • 期号:12
  • DOI:10.3390/bios11120503
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Neural interfaces typically focus on one or two sites in the motoneuron system simultaneously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating microarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.
  • 关键词:invasive; motor pathway; electrophysiology; microelectrode array; wireless; spinal cord; peripheral nerve
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