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  • 标题:Hapten Synthesis and Monoclonal Antibody Preparation for Simultaneous Detection of Albendazole and Its Metabolites in Animal-Origin Food
  • 本地全文:下载
  • 作者:Shibei Shao ; Xuping Zhou ; Leina Dou
  • 期刊名称:Foods
  • 电子版ISSN:2304-8158
  • 出版年度:2021
  • 卷号:10
  • 期号:12
  • DOI:10.3390/foods10123106
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Albendazole (ABZ) is one of the benzimidazole anthelmintics, and the overuse of ABZ in breeding industry can lead to drug resistance and a variety of toxic effects in humans. Since the residue markers of ABZ are the sum of ABZ and three metabolites (collectively referred to as ABZs), albendazole-sulfone (ABZSO 2), albendazole-sulfoxide (ABZSO), and albendazole-2-amino-sulfone (ABZNH 2SO 2), an antibody able to simultaneously recognize ABZs with high affinity is in urgent need to develop immunoassay for screening purpose. In this work, an unreported hapten, 5-(propylthio)-1H-benzo[d
  • 关键词:albendazole; metabolites; hapten design; antibody; immunoassay; computational chemistry
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