标题：Sex Differences in the Associations of Nutrient Patterns with Total and Regional Adiposity: A Study of Middle-Aged Black South African Men and Women
摘要：The study evaluated the association between nutrient patterns with body fat and regional adiposity in middle-aged black South African (SA) men and women and determined if this differed by sex. Body fat and regional adiposity (dual-energy x-ray absorptiometry), and dietary intake (7-day quantified food frequency questionnaire) were measured in black SA men (
n = 414) and women (
n = 346). Using principal component analysis, nutrient patterns were computed from 25 nutrients in the combined sample. Four nutrient patterns were extracted, explaining 67% of the variance in nutrient intake. Animal and fat, as well as the vitamin C, sugar, and potassium driven patterns, were positively associated with total adiposity. In contrast, the retinol and vitamin B12 pattern was associated with the centralisation of fat. Notably, the strength of the association between the animal-driven nutrient pattern and BMI was greater in men (1.14 kg/m
2, 95% CI (0.63–1.66)) than in women (0.81 kg/m
2, 95% CI (0.25–1.36)) (P
int
= 0.017). In contrast, the plant-driven pattern was associated with higher abdominal subcutaneous adipose tissue (SAT) in women (44 cm
2, 95% CI (22–67)) but not men (P
int
= 1.54 × 10
−4). These differences suggest that although men and women have similar nutrient patterns, their associations with the whole body and regional body fat are different.
关键词：nutrient patterns; obesity; sex differences; total and regional adiposity; South Africa
