标题：Commercial microbiota test revealed differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers
摘要：The early-life modifications of intestinal microbiota may impact children's subsequent emotional and cognitive development. Studies show that some bacteria species in gut microbiota, and the lack of others, may play a key role in autism spectrum disorders (ASD) development. Fecal samples were obtained from three groups of children: 16 healthy, 24 with allergies (ALG), and 33 with ASD (probiotics and non-probiotics users). The analysis was carried out according to the KyberKompakt Pro protocol. We observed a significantly higher level of
Klebsiella spp. in the healthy children from the non-probiotics group, considering three groups. In the same group,
Bifidobacterium spp
. the level was lower in ASD compared to neurotypical individuals. In healthy children who did not use probiotics, strong positive correlations were observed in
E. coli and
Enterococcus spp
. and
Bacteroides and
Klebsiella spp., and a negative correlation for
Akkermansia muciniphila with both
Klebsiella spp
. and
Bacteroides spp
. In the ASD group who take probiotics, a strongly negative correlation was observed in
Lactobacillus spp., and both
Faecalibacterium prausnitzii and
Akkermansia muciniphila levels
. In the ALG group, the strongest, negative correlation was found between
Enterococcus spp
. and
Lactobacillus spp
. as in
Akkermansia muciniphila and
Bifidobacterium spp. The simple commercial test revealed minor differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers.
