摘要：During pregnancy and lactation, considerable factors that affect the maternal microbiome are associated with the advancement of numerous diseases, which can potentially affect offspring health. Probiotics have shown potential for the maintenance of microbiota homeostasis of mothers in this period. The specific objective of this study was to investigate whether the application of
Akkermansia muciniphila (
A. muciniphila) during pregnancy and lactation impacts maternal and offspring health. Here we show that dams fed with
A. muciniphila is safe, enhances the intestinal barrier and alters gut microbiota composition and diversity at the end of lactation, including the significant enrichment of
A. muciniphila and
Ruminococcus_1 in offspring from probiotic-fed dams. However, compared with the control group, the fecal metabolites of the
A. muciniphila group only changed slightly. Additionally,
A. muciniphila supplementation did not significantly increase the abundance of
A. muciniphila in the fecal microbiota of offspring mice. Compared with the control group, the fecal metabolic profile of three-week-old offspring of mice fed with
A. muciniphila were significantly changed, containing the D-glutamine and D-glutamate metabolism pathways. These results provided evidence that
A. muciniphila supplementation in mice during pregnancy and lactation is safe and seemed to have a more beneficial effect on dams. In the future, using probiotics to regulate maternal microbiomes during pregnancy and lactation could be shown to have a more lasting and beneficial effect.
