期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2022
卷号：70
期号：1
页码：7-13
DOI：10.3164/jcbn.21-56
语种：English
出版社：The Society for Free Radical Research Japan
摘要：Streptococcus thermophilus bacteria, which are widely used as fermented starter for dairy production, exert various beneficial health effects. Nevertheless, even though pro-longevity effects of various probiotics have been reported, no report has described
Streptococcus thermophilus effects on longevity. This study was conducted to evaluate
Streptococcus thermophilus effects on
lifespan extension and to elucidate the
Streptococcus thermophilus-mediated
longevity mechanism using
Caenorhabditis elegans worms as a model animal. They were fed standard food (
Escherichia coli OP50) or
Streptococcus thermophilus from the young adult stage. Feeding with
Streptococcus thermophilus, compared to
Escherichia coli OP50, to
Caenorhabditis elegans extend the lifespan, reduced lipofuscin accumulation, and maintain vigorous locomotion. Feeding with
Streptococcus thermophilus did not alter the worm growth curve or the offspring number, indicating that the
Streptococcus thermophilus-mediated lifespan extension is not attributable to caloric restriction. The qRT-PCR data showed that
Streptococcus thermophilus increased the expression of
daf-16 and some of its downstream antioxidant genes. Furthermore, the pro-longevity effects of
Streptococcus thermophilus were decreased in loss-of-function mutant of
daf-16. Results show that
Streptococcus thermophilus extends the lifespan of
Caenorhabditis elegans through DAF-16-mediated antioxidant pathway activation.
