首页    期刊浏览 2024年10月07日 星期一
登录注册

文章基本信息

  • 标题:Effects of the Ketogenic Diet in the Treatment of Gliomas: A Systematic Review
  • 本地全文:下载
  • 作者:Beatriz Sargaço ; Patrícia Almeida Oliveira ; Maria Luz Antunes
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2022
  • 卷号:14
  • 期号:5
  • DOI:10.3390/nu14051007
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:The ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft® Excel® was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life.
  • 关键词:enketogenic dietgliomaglioblastomasurvival
国家哲学社会科学文献中心版权所有