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  • 标题:Evaluation of antiplasmodial potential of Beta vulgaris juice in Plasmodium berghei infected mice
  • 本地全文:下载
  • 作者:Haleema H. Albohiri ; Najia A. Al-Zanbagi ; Majed S. Alzahrani
  • 期刊名称:Journal of King Saud University - Science
  • 印刷版ISSN:1018-3647
  • 出版年度:2022
  • 卷号:34
  • 期号:3
  • 页码:1-6
  • DOI:10.1016/j.jksus.2022.101844
  • 语种:English
  • 出版社:Elsevier
  • 摘要:AbstractThe parasite,Plasmodiumsp. is responsible for Malaria, which kills around half a million people annually and its management relies on efforts of cooperation between health care personnel and the public sector. The effect ofBeta vulgarisfresh juice on mice infected by the chloroquine-sensitivePlasmodium berghei bergheithroughin vivotrials was studied in King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. The EDs were estimated for the fresh juice activity and the secondary screening. There were significant differences in the parasitemia level (p= 0.0) between the negative control group and mice treated byB. vulgarisfresh juice and Chloroquine. The mean parasitemia level in infected untreated mice orB. vulgarisfresh juice was significantly differentiated at concentrations ranging from 10% − 80% (p = 0.0). ED50and ED90B. vulgarisfresh juice are estimated to be 24.5 (17.8–33.8) and 40.7 (24–68.8) at 5% confidence limits. This is optimistic and stimulates additional investigation onB. vulgarisfresh juicein vitrotrials and further extraction of the active components ofB. vulgarisagainst malaria.
  • 关键词:KeywordsenPlasmodium bergheiBeta vulgarisChloroquineHerbal medicineAntimalaria
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