摘要：SummaryPrevention of hypoglycemia (glucose <70 mg/dL) during aerobic exercise is a major challenge in type 1 diabetes. Providing predictions of glycemic changes during and following exercise can help people with type 1 diabetes avoid hypoglycemia. A unique dataset representing 320 days and 50,000 + time points of glycemic measurements was collected in adults with type 1 diabetes who participated in a 4-arm crossover study evaluating insulin-pump therapies, whereby each participant performed eight identically designed in-clinic exercise studies. We demonstrate that even under highly controlled conditions, there is considerable intra-participant and inter-participant variability in glucose outcomes during and following exercise. Participants with higher aerobic fitness exhibited significantly lower minimum glucose and steeper glucose declines during exercise. Adaptive, personalized machine learning (ML) algorithms were designed to predict exercise-related glucose changes. These algorithms achieved high accuracy in predicting the minimum glucose and hypoglycemia during and following exercise sessions, for all fitness levels.Graphical abstractDisplay OmittedHighlights•People with type 1 diabetes exercised in eight identically-designed treadmill sessions•Intrapersonal glycemic response varies even under controlled and repeated conditions•Glucose trends downward more quickly in people with higher aerobic fitness•Adaptive ML algorithms predict exercise-related nadir glucose with high accuracyPhysiology; Biocomputational method; Computational bioinformatics
