标题：High Compliance to Mediterranean Diet Associates with Lower Platelet Activation and Liver Collagen Deposition in Patients with Nonalcoholic Fatty Liver Disease
摘要：The Mediterranean diet (Med-Diet) is considered the most effective dietary patterns to obtain weight loss in NAFLD patients. Previous evidence suggested that Med-Diet adherence could reduce cardiovascular risk and have a beneficial effect on NAFLD severity. Aim of the study was to investigate the relationship between Med-Diet adherence, platelet activation (PA), and liver collagen deposition. The study was performed in 655 consecutive NAFLD outpatients from the PLINIO study, a prospective observational cohort study aimed to identify non-conventional predictors of liver fibrosis progression in NAFLD. PA was measured by the serum thromboxane B
2 (TxB
2), and liver collagen deposition by N-terminal propeptide of type III collagen (Pro-C3). Adherence to the Med-diet was investigated by a short nine-item validated dietary questionnaire. Patients with high Med-Diet adherence were older and had less metabolic syndrome and lower serum triglycerides, GGT, TxB
2, and Pro-C3. At multivariate regression analyses, in the linear model, the Med-Diet score negatively correlated with both TxB
2 (Beta = −0.106;
p = 0.009) and Pro-C3 (Beta = −0.121;
p = 0.002) and in the logistic model high adherence inversely correlated with higher TxB
2 tertiles (II tertile: OR = 0.576,
p = 0.044; III tertile: OR = 0.556,
p = 0.026) and Pro-C3 tertile (III tertile: OR = 0.488,
p = 0.013). Low consumption of red meat inversely correlated with higher TxB
2 tertile (II tertile: OR = 0.448,
p < 0.001, III tertile: OR = 0.567,
p = 0.004). In conclusion, NAFLD patients with high adherence to the Med-Diet show lower PA and liver collagen deposition, suggesting a protective role of the Med-Diet against NAFLD progression and cardiovascular risk. In addition, the correlation between TxB
2 and Pro-C3 suggests a link between NAFLD severity and cardiovascular risk.
