摘要:This paper discusses the theoretical and methodological principles in the process of regionalization and analyzes the criteria used during the designation of the region as a category of special importance in geographical research. Methodological principles of regionalization were applied during the differentiation of the Preševo Valley as an individualized region. The Preševo Valley is a small region in South Serbia with a very favorable geographical position because it is located in the central part of the Balkan Peninsula between the Morava and Vardar valleys. Theoretical and methodological discussion highlights elements of a geographical and socio-economic basis that contribute to a regional-geographical differentiation of the area, as well as those elements that appear as an obstacle in attempts to differentiate this area in regional terms. A critical overview of the use of the name ‘Preševo Valley’ between scientific argumentation and political usage is also given. A survey was carried out to identify the main elements that constitute Preševo Valley’s regional identity. The main results show that this region is characterized by a mostly Albanian population, poor economic development, high migration rates, strategic position, and a strong national consciousness.