摘要：Candida spp. is most common opportunistic pathogen in HIV/AIDS patients causing severe and rapidly progressive, difficult to diagnose and often refractory to therapy. In the era of emergence of resistance among different microorganisms due to various factors, Candida spp are among those microbes that have to be extensively studied in the areas of pathogenic and virulence determinants. Coagulase emzyme is considered as a virulence factor in Staphylococci and that has been studied least in Candida spp as evidenced by available literature. We have attempted to evaluate the coagulase activity among Candida spp isolated from HIV seropositive patients. This prospective study included 179 Candida isolates from HIV seropositive patients presenting with various clinical conditions of candidiasis. Identificaton was carried out as per standard procedures and the coagulase activity was detected by tube coagulase method using three different animal plasmas. Among 179 clinical isolates of Candida tested, high coagulase activity was observed with rabbit plasma (55%) followed by sheep plasma (40.2%). Only C. albicans and C. tropicals showed coagulase activity with Human plasma.
关键词：Candida spp; HIV seropositive individuals; coagulase activity
