摘要：Hpercholesterolemia is closely related to oxidative damages from high fat and cholesterol intakes. The geranyl flavonoid (GF) from Artocarpus altilis (Breadfruit) has potential antioxidant, anti-hyperlipidemia and anti-atherogenic properties. This work was to investigate the influence of GF on synthesis of cholesterol and lipogenesis in hypercholesterolemic rat fed with high-cholesterol diet. Treatment with GF significantly increased SOD, CAT, GPx and GR activities in organ tissues, as well as decreased TBARS activity compared to the untreated group. Total glutathione, NO and α-tocopherol contents in liver, kidney and adipose tissues in GF treated group were also higher than that in untreated group. In addition, the GF treatment increased ACAT and fatty acid synthase activities, and decreased HMG-CoA reductase activity. The results suggest that treatment of GF could inhibit the synthesis of cholesterol and the lipogenesis by regulating ACAT, HMG-CoA reductase and fatty acid synthase activities and improving the antioxidant defense status in hypercholesterolemic rat.
