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  • 标题:Standardized Ethanolic Extracts of Boswellia serrata Ameliorate Symptoms of Osteoarthritis by Direct Effects on Chondrocytes
  • 本地全文:下载
  • 作者:Jihee Lee ; Inae Jeong ; Gwang-Woo Kim
  • 期刊名称:Journal of Food and Nutrition Research
  • 印刷版ISSN:2333-1119
  • 电子版ISSN:2333-1240
  • 出版年度:2021
  • 卷号:9
  • 期号:12
  • 页码:614-625
  • DOI:10.12691/jfnr-9-12-1
  • 语种:English
  • 出版社:Science and Education Publishing
  • 摘要:We investigated whether standardized ethanolic extracts of Boswellia (FJH-BS) could alleviate the symptoms of osteoarthritis, including pain, inflammation, and degradation of articular cartilage. Sprague-Dawley rats with monosodium iodoacetate (MIA)-induced osteoarthritis received supplementation of FJH-BS at 80 and 125 mg/kg body weight. We found that FJH-BS supplementation reduced histological and architectural changes and pain levels in rats with MIA-induced osteoarthritis. In addition, FJH-BS supplementation suppressed mRNA expression of matrix metalloproteinases (MMPs) and pro-inflammatory mediators, including cyclooxygenase-2, prostaglandin E2, and pro-inflammatory cytokines. Furthermore, FJH-BS treatment directly suppressed cell death, inflammation, and expression of MMPs in H2O2- or LPS-treated primary chondrocytes. Our results suggest that supplementation with standardized FJH-BS may prevent osteoarthritis progression by directly influencing chondrocytes.
  • 关键词:Boswellia;osteoarthritis;chondrocytes
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