摘要：SummaryThe complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut of 34 years) were exposed to simplified galactic cosmic ray (GCR5-ion; 5-ion sim) irradiation at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratories (BNL). Multi-modal cardiovascular functional assessments performed longitudinally and terminally revealed significant impairment in cardiac function in mice exposed to GCR5-ioncompared to unirradiated controls, gamma irradiation, or single mono-energetic ions (56Fe or16O). GCR5-ion-treated mice exhibited increased arterial elastance likely mediated by disruption of elastin fibers. This study suggests that a single exposure to GCR5-ionis associated with deterioration in cardiac structure and function that becomes apparent long after exposure, likely associated with increased morbidity and mortality. These findings represent important health considerations when preparing for successful space exploration.Graphical abstractDisplay OmittedHighlights•Mice exposed to simplified galactic cosmic ray (GCR5-ion) in controlled setting•Significant cardiovascular dysfunction 1year post exposure to GCR5-ion•Increased arterial elastance, elastin fiber disruption in GCR5-ion-exposed miceCardiovascular medicine; Space medicine; Exposure; Animal physiology; Model organism
