摘要：SummaryThe vibrational and rotational frequencies of most biological macromolecules fall within the terahertz (THz) band; therefore, the THz wave has a strong ability to distinguish substances. Saccharides are important organic substances and the main source of life-sustaining activities. In this study, the spectral characteristics of D-glucose, α-lactose hydrate, and β-maltose hydrate were measured in the solid state through THz time-domain spectroscopy in the frequency range of 0.1–2.5 THz. The crystal configurations of these three saccharides were then simulated using solid-state density functional theory, and the experimental results were found to be in good agreement with the simulation results. Furthermore, the spectral characteristics of the three saccharides in solutions were measured. Each saccharide was found to have unique spectral characteristics, and a correlation existed between the THz absorption spectra of the same substance in the solid state and aqueous solution.Graphical abstractDisplay OmittedHighlights•Solid D-glucose, α-lactose hydrate, and β-maltose hydrate have unique absorption peaks•The simulated results of the three saccharides are consistent with the experimental ones•The THz spectra of the three saccharides in solid and aqueous solutions are correlatedPhysics; Optics; Radiation chemistry
