摘要：The Gly16Arg polymorphism results in a G to C nucleotide mutation in the human beta 2-adrenergic receptor (
ADRB2) gene and has a relationship with obesity; however, this substitution’s effects on food preferences are unclear. Therefore, we determined this relationship among healthy young adults (mean age, 23.4;
n = 52). To evaluate food preferences, four categories of food (sweet, salty, sour, and bitter) along with high-fat foods were evaluated using a self-reporting questionnaire. Male (
n = 26) and female subjects (
n = 26) were genotyped for the polymorphism and further divided into three groups (two homozygous groups, GG, CC; and a heterozygous group, GC). Preference for sour foods in the GG group was higher compared with that in the CC group in females (
p < 0.05). When sweet foods were classified into low- and high-fat subgroups, preference for high-fat sweet foods in the GG group was higher than that for low-fat sweet foods in all subjects (
p < 0.05). The degree of preference for high-fat foods in the GG group was higher than other groups for males (
p < 0.05). These results suggest that
ADRB2 polymorphism is associated with food preference. Understanding the relationship of
ADRB2 substitution to food preference will be valuable for designing individualized anti-obesity strategies.
关键词：enbeta 2-adrenergic receptor (ADRB2)fatty foodsobesitypreference of foodsingle nucleotide polymorphism (SNP)
