标题：Metatypical basal cell carcinoma: from the primary tumour to a generalized metastatic process – description of diagnostics and combination therapy of an extremely rare skin cancer
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2021
卷号：29
期号：1
页码：152-156
DOI：10.26444/aaem/134660
语种：English
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction Basal cell carcinoma (BCC) is the most common form of skin cancer. The hallmarks of this carcinoma are the absence of distant metastases and local malignancy. Metatypical basal cell carcinoma (MTBBC) is rare variant that it is considered to be a more aggressive form, with a higher potential for metastases and recurrence. Probably due to its very rare occurrence, data on pathogenesis, course and treatment are inconsistent. Case report An unusual and very aggressive course of MTBBC with multiple metastases is prtesented. Repeated histopathological evaluation shows the diagnostic difficulties in this type of tumour. Therapeutic attempts, including targeted therapy with vismodegib, were unsuccessful. Conclusions This case showed that it should always be taken into account that each case of diagnosed BCC may turn out to be metatypical variant with a much more aggressive course and worse prognosis. For this reason, intensive follow-up after a completed treatment is recommended.
