摘要：SummaryIt has been suggested that during the period of respiratory worsening of severe COVID-19 patients, viral replication plays a less important role than inflammation. Using the droplet-based digital PCR (ddPCR) for precise quantification of plasma SARS-CoV-2 viral load (SARS-CoV-2 RNAemia), we investigated the relationship between plasma viral load, comorbidities, and mortality of 122 critically ill COVID-19 patients. SARS-CoV-2 RNAemia was detected by ddPCR in 90 (74%) patients, ranging from 70 to 213,152 copies per mL. A high (>1 000 copies/ml) or very high (>10,000 copies/ml) SARS-Cov-2 RNAemia was observed in 46 patients (38%), of which 26 were diabetic. Diabetes was independently associated with a higher SARS-CoV-2 RNAemia. In multivariable logistic regression models, SARS-CoV-2 RNAemia was strongly and independently associated with day-60 mortality. Early initiation of antiviral therapies might be considered in COVID-19 critically ill patients with high RNAemia.Graphical abstractDisplay OmittedHighlights•Plasma SARS-CoV-2 RNA was detected in 90 of 122 COVID-19 critically ill patients•Plasma SARS-CoV-2 RNA was high (>1000 copies per mL) in 46 patients•Diabetic patients had significantly higher levels of plasma SARS-CoV-2 RNA•Plasma SARS-CoV-2 RNA levels were independently associated with day-60 mortalityClinical medicine; Virology ;
