标题：Evaluation of the Effects of the Extracts of Ginger and Aloe Vera on Wistar Rats Model of Type 2 Diabetes Induced With Dexamethasone and High Fat Diet
期刊名称：International Journal of Advances in Engineering and Management
电子版ISSN：2395-5252
出版年度：2021
卷号：3
期号：3
页码：261-271
DOI：10.35629/5252-0303109114
语种：English
出版社：IJAEM JOURNAL
摘要：To investigate the antidiabetic and antihyperlipidemic activities of ginger and aloe vera extracts formulation in dexamethasone induced diabetic wistar rats administered oral doses (100, 200 and 500 mg/kg body weight), eighty four wistar albino rats were used in this study, being divided into fourteen groups of six rats each and fed with high fat diet, inducted with dexamethasone, and treated with Glimepiride, Metformin, Cinnamon, Ginger, and Aloe vera in various doses with the exception of the normal and negative controls. Each sample of blood serum and plasma was analyzed using Randox kits to test for various biochemical and hematological parameters. Compared with the normal control, the mean values of the parameters were significantly different (p<0.05) from each other with few exceptions. The groups treated with Glimepiride, Metformin, and Cinnamon showed improvement. The various doses of Ginger, Aloe vera, and their mixture, showed improvement with an increase in the level as the dose increased. Conclusively, the assessment of insulin resistance studied using the models proved that insulin resistance can be managed when appropriate lifestyle is adopted. These findings support the antihyperglycemic and antihyperlipidemic properties of Glimepiride, Metformin, Cinnamon, Ginger, and Aloe vera in various doses and thus help in preventing future complications of diabetes.
