标题：An Epidemiological Study on the Association between the Total Leukocyte and Neutrophil Counts, and Risk Factors of Ischemic Heart Disease by Smoking Status in Japanese Factory Workers
期刊名称：Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science
印刷版ISSN：1345-3475
出版年度：1998
卷号：17
期号：6
页码：239-247
DOI：10.2114/jpa.17.239
出版社：Japan Society of Physiological Anthropology
摘要：Several epidemiologic studies have shown the association between total leukocyte count and the risk of developing myocardial infarction. The purpose of this study was to assess the association between the total leukocyte and neutrophil counts and risk factors of ischemic heart disease in 1, 384 Japanese factory workers. Total leukocyte and neutrophil counts were significantly higher in current smokers than in non-smokers. Among current smokers, the total leukocyte and neutrophil counts were positively associated with the number of cigarettes smoked daily and the duration of cigarette smoking and alcohol consumption. Being independent of smoking habit, the total leukocyte and neutrophil counts were also related to several characteristics recorded at the physical examinations. The total leukocyte and neutrophil counts were positively associated with serum total cholesterol, serum triglyceride and hematocrit levels, and inversely associated with the serum HDL-cholesterol level. No significant associations of the total leukocyte or neutrophil counts were found with the red blood cell count and hemoglobin level. These results suggest that the total leukocyte and neutrophil counts may represent the metabolic condition with a high coronary risk among apparently healthy people.
