其他摘要：Alzheimer’s disease (Alzheimer’s Disease, AD) is an insidious onset chronic progressive neurological disorders. The clinical manifestations are varying degrees of memory loss and cognitive dysfunction. At present, the pathogenesis and prevention of Alzheimer’s disease are still the hotspots of research. Endoplasmic reticulum stress (ERS) is a protective response of cells to external stimuli. In recent years, many studies have reported that endoplasmic reticulum stress has always run through the occurrence and development of Alzheimer’s disease. The excessive accumulation of β-amyloid (Aβ) and phosphorylated Tau in Alzheimer’s disease can stimulate the occurrence of endoplasmic reticulum stress, which in turn activates the unfolded protein response (UPR), and continues severe endoplasmic reticulum stress will result in apoptosis. Therefore, the author reviews the mechanism and research progress of endoplasmic reticulum stress in the pathogenesis and prevention of AD in recent years.
关键词：阿尔茨海默病;内质网应激;未折叠蛋白反应;Aβ淀粉样蛋白;磷酸化Tau蛋白
其他关键词：Alzheimer’s Disease;Endoplasmic Reticulum Stress;Unfolded Protein Response;Aβ Amyloid;Phosphorylated Tau Protein
