标题：Association between the 5-methyl tetrahydrofolate reductase ( 5-MTHFR) and integrin Β3 subunit ( ITGB3) genes polymorphism and major depressive disorder
摘要：Background and objectivesMajor depression disorder (MDD) is a common condition and syndromic sickness with devastating psychological, social, and economic effects. In general, it is a widespread problem, and the prevalence of MDD varies by country. The genetic contribution to MDD is estimated to be around 35%. This study was done to explore the association between 5-methyl tetrahydrofolate reductase (5-MTHFR) and integrin β3 subunit (ITGB3) genes polymorphism for development of major depressive disorder.Materials and methodsThe current study comprised thirty MDD patients, ranging in age from 18 to 52 years. All of the individuals were diagnosed using the Diagnostic and Statistical Manual of Mental Axis I Disorder in the outpatient departments of Taif Psychiatry Health Hospital (DSM-IV). The three polymorphic markers, C667T and A1298C of the5-MTHFRgene and T1565C of theITGB3gene, were genotyped using the PCR-RFLP method.ResultsThe C667T single nucleotide polymorphism was found to be in heterozygous state in ten patients, while the A1298C single nucleotide polymorphism was not found in any of them. Twenty-one patients had the T1565C single nucleotide polymorphism in theITGB3gene, five of whom were homozygous state and 16 of whom were heterozygous state. Seven patients were discovered to have compound mutations in both genes.Interpretation & conclusionThe current findings could point to a link between MDD and the T allele of the C667T polymorphism in the5-MTHFRgene and the C allele of the T1565C polymorphism in theITGB3gene.
