摘要：The PRediction and Outcome Study on PTSD and PERsonality disorders (PROSPER) is a research project consisting of two parallel RCTs comparing trauma-focused treatment with integrated trauma and personality disorder treatment in patients with PTSD and comorbid borderline or cluster C personality disorder (PD). When the COVID-19 emergency hit The Netherlands in March 2020, we decided to continue both RCTs, partly through online treatments. The objective of this presentation is to share our experiences and to present results on dropout, treatment duration, and COVID-19- related psychological distress within our sample. Method: A total of n = 50 patients filled out questionnaires measuring PTSD severity and COVID-19- related distress. PD symptoms were measured using a structured clinical interview. Hierarchical regression analysis was used to test the associations between PTSD severity, PD symptoms, and COVID19-related distress. Length of treatment and percentage dropout during the pandemic versus prepandemic will be compared. Results: Hierarchical regression analysis revealed a significant positive association between COVID-19-related distress and PTSD severity, independent of PD symptoms. Results for treatment duration and dropout will be presented for both RCTs. Conclusions: Continuing an RCT during the COVID-19 pandemic faced us with unique challenges. Moreover, COVID-19-related distress was significantly associated with PTSD severity. Current findings indicate that patients with pre-existing PTSD and PD pathology should be considered as a vulnerable population in the COVID-19 pandemic and require timely and appropriate mental health care.
