摘要:The article explores demographic problems, such as birth rate decrease, high rate of mortality and structural unemployment in the RF regions through the example of a typical industrial territory - the Sverdlovsk region. The vital rate trends in the Sverdlovsk region are analyzed, where, since 2016, the growing population decline, demographic ageing and shrinking numbers of the economically active population have been observed. The reasons of the current demographic situation in the country and regions, having ample evidence of depopulation, are considered. Providing a simple population replacement mode, addressing social and demographic problems, necessary to increase human resources reproduction efficiency, are essential for the sustainable development of the regional economy. However, this can only be achieved through public administration system improvement and modern technologies implementation. It is proposed to increase the efficiency of interdepartmental interaction between healthcare, educational and labor institutions, which focus at birth rate increase, health improvement, education development, full population employment and provision of economic entities with qualified workforce. In addition, a set of measures is developed to combat depopulation and to improve human resources reproduction policy at the national and regional levels to provide for sustainable development.