摘要:This study analyzed the association and contribution of anxiety, spirituality, coping and burden to quality of life (QOL) in informal caregivers of patients with cervical cancer. The sample included 119 informal caregivers of patients undergoing treatment for cervical cancer at a reference hospital in the state of Amazonas, Brazil. The caregivers answered instruments that assessed sociodemographic variables, burden, coping, anxiety, spirituality, and QOL. Female caregivers used more spirituality (reflection and positive interpretation) than male caregivers. The number of hours of care dedicated by caregivers was positively correlated with their burden. Burden had a positive association with anxiety and was negatively associated with the caregivers’ mental QOL. Spirituality (reflection and positive interpretation) moderated the relationship between anxiety and caregiver’s mental QOL. The results showed the importance of interprofessional teams in oncology to intervene with caregivers, focusing on psychological morbidity to prevent burden and the spirituality as a coping strategy.