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  • 标题:Anti-androgenic Activity of Myricae Cortex—Isolation of Active Constituents from Bark of Myrica rubra
  • 本地全文:下载
  • 作者:Hideaki MATSUDA ; Miho YAMAZAKI ; Keizo MATSUO
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2001
  • 卷号:24
  • 期号:3
  • 页码:259-263
  • DOI:10.1248/bpb.24.259
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra SIEB. et ZUCC., Myricaceae) showed in vitro testosterone 5α-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.
  • 关键词:Myrica rubra;testosterone 5α-reductase;anti-androgenic activity;hair regrowth
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