摘要：16α,19-Dihydroxyandrostenedione [16α,19-(OH)2 AD], a potential precursor of estriol, was identified in the serum of pregnant women by gas chromatography-mass spectrometry (GC-MS). Preliminary study indicated that the average serum concentration of 16α,19-(OH)2 AD in 10 normal pregnant women was 154.2±20 pg/ml. In contrast, the serum concentration of 16α,19-dihydroxydehydroepiandrosterone was less than the detection limit (30 pg/ml) of the GC-MS method.
关键词：16α,19-dihydroxy androgen;serum concentration;pregnant woman;estriol formation;feto-placental unit
