摘要：A series of novel 2-phenyl-3-substituted quinazolin-4(3 H )-ones have been synthesized by treating methyl- N -(2-phenyl quinazolin-3-yl-4(3 H )-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.
