摘要：Four steviol ( ent -kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana B ERTONI . These compounds showed strong inhibitory activity against 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1—291.6 μg/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 μg/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[ a ]anthracene (50 μg/mouse).
