标题：Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.—Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion
摘要：7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum Michx. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein–Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12- O -tetradecanoyl-phorbol-13-acetate (TPA) in 7,12-dimethylbenz[ a ]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.
