文章基本信息

标题：Mass Spectrometric Separation and Determination of N1, N12-Diacetylspermine in the Urine of Cancer Patients
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作者：Masaki Kobayashi ; Keijiro Samejima ; Kyoko Hiramatsu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2002
卷号：25
期号：3
页码：372-374
DOI：10.1248/bpb.25.372
出版社：The Pharmaceutical Society of Japan
摘要：An ionspray ionization mass-spectrometric method for the determination of N ¹, N ¹²-diacetylspermine (Ac₂Spm) was developed using ¹⁵N-labeled Ac₂Spm as the internal standard. Concentrations of Ac₂Spm in the urine obtained from 17 cancer patients measured by the present method correlated well with those measured by ELISA, showing the usefulness of the two methods.
关键词：diacetylspermine;IS-MS;15N-polyamine;biomarker;cancer;analysis of urine