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  • 标题:Neuritogenesis of Herbal (+)- and (−)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells
  • 本地全文:下载
  • 作者:Kenzo Chiba ; Matsumi Yamazaki ; Emiko Umegaki
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2002
  • 卷号:25
  • 期号:6
  • 页码:791-793
  • DOI:10.1248/bpb.25.791
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Syringaresinol isolated from Epimedium koreanum N AKAI and Magnolia officinalis R EHD . et W ILS . was subjected to optical resolution by chiral HPLC to give (+)- and (−)-enantiomers. The two syringaresinol enantiomers, as well as a mixture of their glucosides, showed dose-dependent neuritogenesis in a concentration range from 0.24 to 24 μ M in PC12h cells.
  • 关键词:syringaresinol;optical isomer;neuritogenesis;PC12h cell;Epimedium koreanum
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