摘要：A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3′,4′,5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 μ M ) exhibited more potency than Kojic acid (IC50; 77.4 μ M ) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.
