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  • 标题:Screening of South American Plants against Human Immunodeficiency Virus: Preliminary Fractionation of Aqueous Extract from Baccharis trinervis
  • 本地全文:下载
  • 作者:Sonsoles Sanchez Palomino ; María José Abad ; Luis Miguel Bedoya
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2002
  • 卷号:25
  • 期号:9
  • 页码:1147-1150
  • DOI:10.1248/bpb.25.1147
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Ethanolic and aqueous extracts of 14 South American medicinal plants were tested for inhibitory activity on human immunodeficiency virus (HIV). Both extracts were relatively non-toxic to human lymphocytic MT-2 cells, but only the aqueous extract of Baccharis trinervis exhibited potent anti-HIV activity in an in vitro MTT assay. To delineate the extract-sensitive phase, some studies of the antiviral properties of the active extract are described in this paper. Based on the results presented here, a separation scheme was devised, which permitted the preliminary fractionation of the extract, with the aim of finding an inhibitor of this virus.
  • 关键词:South American medicinal plant;antiviral activity;Baccharis trinervis;HIV;AIDS
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