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标题：Antimalarial Activity of Herbal Extracts Used in Traditional Medicine in Korea
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作者：Hyun Park ; Myung Soo Kim ; Byung Hun Jeon 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：11
页码：1623-1624
DOI：10.1248/bpb.26.1623
出版社：The Pharmaceutical Society of Japan
摘要：Aqueous extracts of 6 traditional Korean medicines used to treat malaria were tested in vitro for their antimalarial activity against Plasmodium falciparum . The EC₅₀ values for the herbal extracts were in the range 1.4—8.1 μg/ml. Significant antimalarial activity was observed with Coptis japonica (EC₅₀=1.4 μg/ml), but it demonstrated no selective toxicity (selectivity = 1). In contrast, Kalopanax pictus showed antimalarial activity (EC₅₀=4.6 μg/ml) and higher selective toxicity (>4). This indicated that K. pictus may be potent for a new antimalarial agent.
关键词：Plasmodium falciparum;traditional Korean medicine;antimalarial drug;drug-resistant malaria;Coptis japonica;Kalopanax pictus