摘要：We found that glufosinate ( DL -GLUF) was distributed in the spinal fluid in glufosinate poisoning. A 50-year old Japanese man (weighing 67 kg) attempted to commit suicide by ingesting about 100 ml of BASTA (containing DL -GLUF 18.5 g; ratio of D -GLUF to L -GLUF: 1 : 1). He was transported to our hospital, where serious respiratory depression was seen 26 h after ingestion, and management with artificial ventilation was initiated. The D -GLUF concentration 1 h after ingestion was 191.1 μg/ml, almost the same as that of L -GLUF 193.5 μg/ml, but by 3 h after ingestion, these levels had sunk to 60.3 μg/ml and 52.3 μg/ml, respectively, with the concentration of L -GLUF lower than that of D -GLUF. Later, at 27 and 35 h after ingestion, the D -GLUF level was still higher than the L -GLUF level, and the total amounts of urinary excretion were 2835 mg for D -GLUF and 2298 mg for L -GLUF, each variable thus showing a difference between the enantiomers. Cerebrospinal fluid taken from the patient 27 h after poison ingestion revealed the presence of DL -GLUF on CG-MS analysis, and quantitative HPLC analysis of the enantiomers indicated that the D -GLUF concentration was 0.48 μg/ml, and the L -GLUF concentration 0.12 μg/ml. The levels in blood collected at the same time were: D -GLUF, 1.44 μg/ml, and L -GLUF, 0.35 μg/ml. Also, the cerebrospinal fluid contained about one-third of the blood levels of both DL -GLUF enantiomers. He was discharged without any sequelae after 11 d of hospitalization.
