摘要：A series of novel 2-benzylamino-3-substituted quinazolin-4(3 H )-ones have been synthesized by treating 3-amino-2-benzylamino quinazolin-4(3 H )-one, with different aldehydes and ketones. The starting material 3-amino-2-benzylamino quinazolin-4(3 H )-one was synthesized by nucleophilic substitution of thiomethyl group of 3-amino-2-methylthio quinazolin-4(3 H )-one by benzylamine. The title compounds were investigated for analgesic and anti-inflammatory activities. All the test compounds exhibited significant analgesic activity, whereas the compound III is equipotent with diclofenac sodium. The compounds I, II and III showed more potent anti-inflammatory activity than diclofenac sodium.
