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  • 标题:Activation of the Aryl Hydrocarbon Receptor by Some Vegetable Constituents Determined Using in Vitro Reporter Gene Assay
  • 本地全文:下载
  • 作者:Yoshiaki Amakura ; Tomoaki Tsutsumi ; Masafumi Nakamura
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2003
  • 卷号:26
  • 期号:4
  • 页码:532-539
  • DOI:10.1248/bpb.26.532
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological action of many aromatic environmental pollutants. In this study, we investigated the activation of the AhR by some vegetable constituents using the AhR-based bioassay for dioxins, i.e. , the chemical activated luciferase gene expression (CALUX) assay. Ninety-five vegetable constituents, including flavonoids, tannins, saponins, and terpenes, were tested in vitro . Among them, isoflavones such as daidzein, resveratrol having a stilbene structure, and some flavonoids such as naringenin, hesperetin, and baicalein showed AhR activation.
  • 关键词:food;vegetable constituent;aryl hydrocarbon receptor;dioxin;chemical activated luciferase gene expression (CALUX) assay
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