标题：Inhibition of Intracerebroventricular Injection Stress-Induced Plasma Corticosterone Levels by Intracerebroventricularly Administered Compound K, a Ginseng Saponin Metabolite, in Mice
摘要：Effects of major intestinal metabolites of ginsenosides, including compound K (IH-901, 20- O -β- D -glucopyranosyl-20( S )-protopanaxadiol), compound Y (IH-902, 20- O -[α- L -arabinopyranosyl (1→6)-β- D -glucopyranosyl]-20( S )-protopanaxadiol), and ginsenoside Mc (IH-903, 20- O -[α- L -arabinofuranosyl (1→6)-β- D -glucopyranosyl]-20( S )-protopanaxadiol), on acute stress-induced plasma corticosterone levels were studied in mice. Intracerebroventricularly (i.c.v.) administered compound K (1 μg) attenuated the i.c.v. injection stress-induced increase in plasma corticosterone level, and this inhibitory effect was not affected by co-administered N G-nitro- L -arginine methyl ester, a nitric oxide synthase inhibitor. Compound K administered intraperitoneally affected neither the i.c.v. injection stress- nor the immobilization stress-induced increase in plasma corticosterone levels. Compound K and ginsenoside Mc did not affect plasma corticosterone levels induced by the two stress modalities used in this study.
