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  • 标题:Antimicrobial Activity of Some Pentacyclic Triterpenes and Their Synthesized 3-O-Lipophilic Chains
  • 本地全文:下载
  • 作者:Uppuluri Venkata Mallavadhani ; Anita Mahapatra ; Kaiser Jamil
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2004
  • 卷号:27
  • 期号:10
  • 页码:1576-1579
  • DOI:10.1248/bpb.27.1576
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The major metabolites of Diopsyros melanoxylon viz. amyrins and ursolic acid and their lipophilic 3- O -fatty acid ester chains (C12—C18), which are synthesized now under mild esterification conditions in excellent yields (80—95%), were evaluated for their antimicrobial activity against a series of Gram positive and Gram negative bacteria. Significantly these compounds were found to exhibit potent activity against Gram negative bacteria Pseudomonas syringae (ATCC #13457) and fairly good activity against Gram positive bacteria, Bacillus sphaericus (ATCC #14577) and Bacillus subtilis (ATCC #6051).
  • 关键词:antimicrobial activity;triterpene;amyrin;ursolic acid;fatty acid ester;lipophilicity
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