摘要：A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (−)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.
关键词：Piper nigrum;cubebin;3,4-dimethoxy-3,4-desmethylenedioxycubebin;3-desmethoxycubebinin;murine B16 melanoma cell;stimulatory effect on melanogenesis
