首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:Apocynum venetum Extract Does Not Induce CYP3A and P-Glycoprotein in Rats
  • 本地全文:下载
  • 作者:Michiya Kobayashi ; Hiroshi Saitoh ; Shujiro Seo
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2004
  • 卷号:27
  • 期号:10
  • 页码:1649-1652
  • DOI:10.1248/bpb.27.1649
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:We investigated the effect of Apocynum venetum L. extract (AV) on the activity of cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp). The plasma concentration of nifedipine (NF), which is a substrate for CYP3A, did not change after oral administration with AV (3.3 mg/kg). Also, AV (3.3 and 33 mg/kg) did not affect the intestinal absorption of NF. In the rats treated with multiple administrations (15 mg/kg/d) of St. John's wort extract (SJW) for 2 weeks, the plasma concentration of NF after oral administration was significantly decreased. On the other hand, there was no significant differences in the pharmacokinetic parameters of NF between AV-treated (3.3 mg/kg/d) and none-treated rats. Furthermore, the intestinal absorption of methylprednisolone, which is a substrate for P-gp, was not affected by AV treatment for 2 weeks. These results suggest that, unlike SJW, the recommended dose of AV (3.3 mg/kg/d) would not influence hepatic CYP3A and intestinal P-gp in rats.
  • 关键词:Apocynum venetum;St John's wort;CYP3A;P-glycoprotein;rat
国家哲学社会科学文献中心版权所有