摘要：Nine quinolone alkaloids (1—9) from the fruits of Evodia rutaecarpa were investigated for their inhibitory activity on nuclear factor of activated T cells (NFAT)-dependent transcription in comparison with nuclear factor (NF)-κB-dependent transcription using a reporter gene assay. These alkaloids showed inhibitory effects against NFAT activity, with IC50 values between 0.91 μ M and 15.91 μ M . Of the N -methylated quinolones, the longer aliphatic side chain at the quinolone ring showed stronger inhibition of NFAT activity. These N -methylated compounds showed comparable inhibitory effects against NF-κB activity. However, quinolone alkaloids without the N -methyl group showed a more selective inhibition of NFAT activity.
关键词：Evodia rutaecarpa;quinolone alkaloid;nuclear factor activated T cell;nuclear factor-κB
