摘要：Twenty-eight 3-hydroxy triterpenoids of taraxastane- (1—7), oleanane- (8—12), ursane- (13—15), lupane- (16,18,19), taraxane- (20), cycloartane- (21—25), tirucallane- (26—28), and dammarane-types (29) isolated from the non-saponifiable lipid fraction of the flower extract of chrysanthemum ( Chrysanthemum morifolium ) and one lupane-type 3α-hydroxy triterpenoid (17) derived from 16 were tested for their antitubercular activity against Mycobacterium tuberculosis strain H37Rv using the Microplate Alamar Blue Assay (MABA). Fifteen compounds showed a minimum inhibitory concentration (MIC) in the range of 4—64 μg/ml, among which maniladiol (9; MIC 4 μg/ml), 3-epilupeol (17; 4 μg/ml), and 4,5α-epoxyhelianol (27; 6 μg/ml) exhibited the highest activity. Cytotoxicity of compound 17 against Vero cells gave an IC50 value of over 62.5 μg/ml, suggesting some degree of selectivity for M. tuberculosis .
