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  • 标题:Inhibition of Lipid Droplet Accumulation in Macrophages by Triterpenoids Produced from Torametes orientaris
  • 本地全文:下载
  • 作者:Taichi Ohshiro ; Ichiji Namatame ; Kana Ochiai
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2005
  • 卷号:28
  • 期号:10
  • 页码:1925-1927
  • DOI:10.1248/bpb.28.1925
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Four triterpenoids 1—4 isolated from the fruit body of Torametes orientaris were found to inhibit lipid droplet accumulation in macrophages. From the biochemical analysis, compounds 2 and 3 inhibited selectively cholesteryl ester synthesis in macrophages, while compounds 1 and 4 showed inhibition of both cholesteryl ester and triacylglycerol syntheses.
  • 关键词:lipid droplet accumulation;triterpenoid inhibitor;atherosclerosis;macrophage;neutral lipid synthesis;Torametes orientaris
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